John Constantine, a demon hunter and dabbling master of the occult, must struggle with his past sins while protecting the innocent from the converging supernatural threats that constantly break through to our world due to the "Rising Darkness". Balancing his actions upon the line of good and evil, Constantine uses his skills and a supernatural scry map to journey the nation to send these terrors back to their own world, all in the hope of redeeming his soul from eternal torment.
Deep in the mountains of Western Pennsylvania, John is a small mining community's only defense against an ancient Welsh spirit. In the course of protecting these isolated innocents, John finds a vital new ally in a mysterious young woman named Zed.
John and Zed engage in a dangerous confrontation to save a woman and her family from sinister forces. John's efforts force him to confront the darkness in his own life – while also coming face to face with a new powerful adversary in Papa Midnite.
In New Orleans, Constantine's unusual knowledge of a string of crimes gets him into trouble with Detective Jim Corrigan. He must form an unholy alliance with Papa Midnite when a voodoo ritual to help people communicate with their dead loved ones takes a deadly turn.